Alenezi F, Bloomfield GS, Okeke NL, et al. - In patients living with human immunodeficiency virus (PLHIV), researchers assessed if immune status was related to left ventricular (LV) function in order to clarify if HIV-associated immune dysfunction is related to preclinical LV dysfunction, even with normal LV ejection fraction (LVEF). At Duke University Medical Center, they performed global longitudinal strain (GLS) analyses between 2001 and 2012. The studied cohort had a median GLS of – 15.1% with interquartile range from (−16.7 to −13.6). A significant inverse correlation of proximal CD4 < 500 cells/mm³ and nadir CD4 < 250 cells/mm³ with GLS was revealed in adjusted analyses. For the first time ever, a high prevalence of abnormal GLS in PLHIV was reported in this study. Also, the independent link of proximal and nadir CD4 cell count with GLS, even with normal LVEF, was demonstrated for the first time.