Santos-Bezerra DP, et al. - Researchers evaluated the frequency of 5 single-nucleotide polymorphisms in the gene encoding deoxyribonucleic acid methyltransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414, and rs10854076), to examine their relationships with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy in 359 subjects with long-term type 1 diabetes. Overall, they noted that no single-nucleotide polymorphisms were significantly correlated with the presence of chronic complications. Although after sex stratification, they noticed a risk for cardiovascular neuropathy in females due to the presentation of minor allele C of rs11085721 after adjustment for confounding variables.