Islam MA, et al. - Evidence from the last 20 years of research indicates that antiphospholipid syndrome (APS) is a polygenic disorder, where a number of genes are involved in the development of its clinical manifestations. In this current systematic review, researchers assessed the genetic risk factors in thrombotic primary APS, and used bioinformatic analyses to assess the common molecular functions, biological processes, pathways, interrelations with the gene encoded proteins and RNA-Seq-derived expression patterns over different organs of the associated genes. They identified that in comparison with controls, 16 genes contributed significantly in patients with thrombotic primary APS. Bioinformatic analyses of these genes revealed their molecular interconnectivity in protein levels largely by affecting blood coagulation and immune system. The expression of these genes was apparent in 32 different organs and these genes may confer a higher risk of developing thrombosis anywhere in the body of primary APS patients.