Liu Z, Suo C, Zhao R, et al. - The findings revealed that avoiding obesity and adhering to a healthy lifestyle is important to preventing nonalcoholic fatty liver disease (NAFLD) progression.

• Researchers recruited a total of 78,283 individuals, 35,159 (44.9%) were females, and the mean (SD) age was 57.56 (7.90) years.

• In comparison with individuals who had both low genetic and lifestyle risk, individuals with both high genetic and lifestyle risk had a hazard ratio of 1.64 (95% CI 1.32–2.03) for significant liver diseases (SLDs), 1.16 (1.08–1.24) for type 2 diabetes, 1.25 (1.13–1.37) for cardiovascular diseases (CVDs), 1.33 (1.18–1.49) for chronic kidney diseases (CKDs), and 1.13 (1.05-1.22) for cancers.

• Compared with participants who were non-obese and had low genetic risk, those with obesity and high genetic risk had a 75% (95% CI 38–123%), 147% (128–167%), 46% (33–61%), and 76% (56–99%) increased risk for developing SLDs, type 2 diabetes, CVDs, and CKDs, respectively.

• According to the findings, the population-attributable fractions implied that lifestyle risk and obesity contributed more to the progression of NAFLD than genetic risk.