Brhane Y, Yang P, Christiani DC, et al. - By performing a genome-wide investigation using the International Lung Cancer Consortium (ILCCO), researchers evaluated never smokers for genetic determinants for lung cancer prognosis. They analyzed data from 1,569 never-smoking patients with lung cancer of European ancestry from 10 ILCCO studies. They also evaluated if the links were mediated via mRNA expression–based 1,553 normal lung tissues from the lung expression quantitative trait loci dataset and Genotype-Tissue Expression. One locus at 13q22.2 was identified to be related to lung adenocarcinoma survival at genome-wide level, with rs12875562-T allele carriers showing poor prognosis, and changed mRNA expression of LMO7DN in lung tissue. In both European and Japanese populations, the associations of one locus encoding NWD2/KIAA1239 at 4p14 were found. On the basis of findings of the largest genomic inquiry of lung cancer prognosis of never smokers to date, it is clear that inherited genetic variants impact lung cancer prognosis.