Sathe M, Huang R, Heltshe S, et al. - In infants with cystic fibrosis (CF), a higher risk for gastrointestinal-related (GI-related) admission during the first 12 months was observed in relation to factors such as high pancreatic enzyme replacement therapy dosing, exposure to acid suppressive medications, higher fecal calprotectin levels, and/or relative abundance of fecal K pneumoniae early in life.

• A longitudinal, observational cohort (Baby Observational and Nutrition Study) of 231 infants diagnosed with CF by newborn screening.

• Among participants, 65 patients had at least one admission in the first 12 months of life.

• Lower weight-for-length z scores at 12 months of age was observed in infants with CF needing GI-related hospitalization vs those not admitted as well as those admitted for non-GI-related indications.