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Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants

Thorax Oct 11, 2017

Delgado-Eckert E, et al. - With an intent to identify subgroups of asthmatic participants with specific lung functional features, researchers proposed and validated a novel clustering approach to asthma phenotyping, which exploits the information contained within the fluctuating behaviour of twice-daily lung function measurements. Dynamic functional asthma and healthy phenotypes were determined using the method proposed by researchers. These phenotypes were partly independent of atopy and inflammation but showed association with genetic markers on the 17q21 locus. Furthermore, this method can assist disease phenotyping and possibly endotyping and, possibly detect participants with specific functional abnormalities, potentially needing a different therapeutic approach.
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