McGowan K, et al. - Since the role of immune function in susceptibility to medication-related osteonecrosis of the jaws (MRONJ) remains unclear, researchers examined if full blood counts, as a measure of systemic health and immune function, predict the development of MRONJ. A total of 57 cases diagnosed with MRONJ were identified from hospital records from January 2010 to March 2017 and matched individually with up to 4 controls using primary disease, sex, age, and antiresorptive therapy. Using conditional logistic regression, demographic and clinical data were extracted and associations were investigated. Low hemoglobin and low hematocrit were the most commonly reported abnormal results. According to findings, patients taking antiresorptive medicines frequently return blood test results outside the standard reference range of the laboratory. Altered blood counts were not limited to patients with MRONJ and do not seem to be clinically useful in identifying high-risk patients for this condition. In any of the reported parameters, there were no significant differences between groups.