Rubio-Suarez JC, et al. - Researchers sought for the variables that could be related to complications and sequelae in fractures of the tibial pilon treated by open reduction and internal fixation (ORIF) with a locking compression plate-less invasive stabilising system (LCP-LISS). Analysis of a total of 137 fractures treated by ORIF in a 7-year period was performed. Type 43C3 fractures of the AO classification demonstrated a higher rate of skin necrosis and flap coverage. The use of a medial plate was related to a higher rate of nonunion than the use of a lateral plate. Open fractures were related to a higher prevalence of nonunion and flap coverage. A higher prevalence of fair and poor results was noted in relation to both infection and a suboptimal anatomic reduction. Compared to the anterolateral approach, the anteromedial approach was associated with a higher prevalence of skin necrosis and early post-traumatic ankle osteoarthritis. Findings thereby suggest the paramount significance of optimal reduction and stable fixation in diminishing the rate of complications and sequelae after ORIF (LCP-LISS) of these fractures.