Almeida LF, et al. - Researchers assessed fluoride dentifrice (FD) treatment for its possible efficacy in improving the low resistance of fluorotic enamel to demineralization. They used paired enamel slabs of sound and fluorotic enamel (n = 20/group) from human teeth presenting Thylstrup and Fejerskov index scores from 0 to 4. With respect to enamel mineralization and fluoride concentration, they used half of the anatomic surface of the enamel slabs as a control (baseline). The slabs were submitted to a pH-cycling model simulating a high cariogenic challenge. Then they used placebo dentifrice or FD (1,100 µg F/g, as NaF) to treat these slabs 2×/day. They cut the slabs into two halves after 10 days. According to the findings, the use of FD led to a reduction in the higher susceptibility of fluorotic enamel to demineralization lesions.