Rajdev K, Leifer L, Sandhu G, et al. - In this study including 104 cases and 111 controls, researchers calculated the percentage of end-stage renal disease (ESRD) patients on hemodialysis (Case) who were administered ≥ 30 mL/Kg fluid resuscitation within the first 6 h vs non-ESRD patients (Control) with severe sepsis (SeS) or septic shock (SS). They also determined how intubation rate, requirement for urgent dialysis, hospital length of stay (LOS), intensive care unit (ICU) admission and LOS, need for vasopressors, and hospital mortality, all were influenced by fluid resuscitation. They analyzed medical records of 715 patients with sepsis, SeS, SS, and ESRD. The receipt of ≥ 30 mL/Kg fluids was recorded in 23% of patients in the Case group vs 60% in the Control group. The two groups did not differ significantly in terms of mortality, need for urgent dialysis, intubation rates, ICU LOS, or hospital LOS. Findings revealed low compliance with 30 mL/Kg fluids for all patients but this was significantly lower for ESRD patients. The results were suggestive of the safety of aggressive fluid resuscitation in ESRD patients.