Miyata M, et al. - Authors assessed the 5-year visual and anatomical outcomes following anti-vascular endothelial growth factor (VEGF) therapy alone or in combination with photodynamic therapy (PDT), followed by pro re nata (PRN) anti-VEGF therapy with or without PDT, for polypoidal choroidal vasculopathy (PCV). Results demonstrated a limited effect a PRN regimen for PCV for the long-term maintenance of improved visual acuity (VA). They noted the more frequent occurrence of macular atrophy with combination therapy and its probable association with the 5-year VA. Therefore, a careful selection of combination therapy for patients susceptible to macular atrophy was suggested.