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Five-year follow-up of new cases after a coeliac disease mass screening

Archives of Diseases in Childhood Dec 22, 2021

Sandström O, Norström F, Carlsson A, et al. - Findings from this follow-up study revealed that the risk of conversion to coeliac disease was high in those with potential disease. However, within a follow-up span of 5 years, a very low risk for a clinical diagnosis was found in relation to a negative screening test.

  • A previous population-based mass screening of coeliac disease among children aged 12 years in two birth cohorts revealed seropositivity in 296 children, of whom 242 received a diagnosis of coeliac disease after duodenal biopsies.

  • Seropositive ones were called for a follow-up 5 years post-screening with renewed serological testing and recommended endoscopic investigation if seropositive; 230 (77%) attended the follow-up, including 34 of 39 with potential coeliac disease.

  • Conversion to coeliac disease occurred in 32% of these (n=11).

  • In the National Swedish Childhood Coeliac Disease Register, there was one new case that was diagnosed via routine screening in children with type 1 diabetes.

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