Blom S, et al. - Since tumor stroma is correlated with progression in prostate cancer (PCa), researchers described its particular cellular composition and relationship with patient survival outcome by assessing stromal composition in human PCa. They used multiplex immunohistochemistry and quantitative, high-resolution image analysis in two formalin-fixed paraffin embedded observational clinical retrospective cohorts. A large proportion of fibroblasts correlated with aggressive disease and castration-resistant prostate cancer (CRPC). In the two clinical cohorts analyzed, an elevation in proportion of fibroblasts prognosticated poor cancer-specific outcome independently. Hence, in order to discover the prognosis in PCa, fibroblasts were concluded as the most significant cell type associated with CRPC. Also, for the development of the diagnostic and therapeutic approaches to aggressive prostate cancer, the stromal composition could be critically significant.