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Fertility preservation in Turner Syndrome: Karyotype doesn't predict ovarian response to stimulation

Clinical Endocrinology Aug 23, 2019

Vergier J, et al. - Because Turner syndrome (TS) is liable for high-risk gonadal dysgenesis of premature ovarian insufficiency, researchers in this population wanted to learn about strategies for fertility preservation (FP). From 2014 to 2018, data from TS women consulting with a fertility specialist in the FP center were gathered retrospectively. Nine TS women have been referred. For oocyte vitrification, three women with different karyotypes had controlled ovarian stimulation (COS). Mean age was 13.7 years [9-20] at TS diagnosis. According to findings, AMH and FSH levels seemed to be accurate predictive markers of oocyte cryopreservation achievement regardless of karyotype, antral follicular count. With a high number of retrieved oocytes, cryptic ovarian mosaicism could explain a successful ovarian response to stimulation in a monosomic TS woman. In the event of spontaneous menarche, TS adolescents should be referred for FP counselling during the transition to adulthood to prevent referral delay and time-related reduced ovarian reserve.
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