Xue JH, Xie YH, Zou TH, et al. - In the present study, the researchers sought to evaluate the outcomes of colorectal adenoma patients undergoing polypectomy and to identify risk factors for metachronous adenoma by paying close attention to the role of fecal Fusobacterium nucleatum. Fecal samples and clinical information were collected from 367 patients in a retrospective cohort and 238 patients in a prospective cohort prior to endoscopic polypectomy. The abundance of fecal Fusobacterium nucleatum was measured through quantitative PCR. In the retrospective cohort, a high abundance of fecal Fusobacterium nucleatum was found to be an independent risk factor for metachronous adenomas, and this was validated in the prospective cohort with a specificity of 65.00%, and a sensitivity of 73.04%, and overall performance with the area under the curve of 0.73. Findings suggested that fecal abundance of F. nucleatum may be a reliable predictor for metachronous adenoma following endoscopic polypectomy.