Copova I, et al. - This study was undertaken to determine if the difference between basal fecal calprotectin (F-CPT) and the value at week 2 of exclusive enteral nutrition (EEN) could be used to forecast clinical response at week 6. For this investigation, stool samples were prospectively collected from 38 pediatric patients with newly diagnosed active luminal Crohn disease (CD) during EEN for F-CPT analysis and clinical and laboratory parameters. Findings revealed that the difference between the F-CPT concentrations before EEN treatment and at week 2 did not anticipate the clinical response to treatment at week 6; it anticipated clinical remission with low accuracy. The study findings suggested that F-CPT is not a suitable predictor to choose the patients for whom EEN induction therapy should be stopped.