Sporns PB, Sträter R, Minnerup J, et al. - In this retrospective, multicenter cohort study, done from January 1, 2000, to December 31, 2018, investigating the databases from 27 stroke centers in Europe and the United States, of 73 children, experts assessed the use of endovascular recanalization in pediatric patients with arterial ischemic stroke. Sixty-three children got treatment for anterior circulation occlusion and ten for posterior circulation occlusion, including 16 who got concomitant intravenous thrombolysis. One acquired a postinterventional bleeding complication four transient peri-interventional vasospasm. In conclusion, the results of this study imply that the safety profile of thrombectomy in childhood stroke does not vary from those in randomized clinical trials for adults and most of the treated children had positive neurologic outcomes. Furthermore, in childhood stroke in the absence of high-level proof, this could support clinicians’ practice of off-label thrombectomy.