Masic S, Strother M, Kidd LC, et al. - Renal mass biopsies (RMB) should not be postponed in patients with anatomically complex renal masses because RMB in such cases offer an excellent diagnostic yield, although lower than non-complex lesions, which could improve clinical decision-making.

• Institutional renal tumor database was used.

• A total 306 RBMs were included, 179 complex and 127 non-complex.

• Complex lesions were less likely to have an adequate biopsy, and to be concordant with final surgical pathology from an oncologic standpoint.

• Only male gender was related to biopsy adequacy.

• The overall sensitivity, specificity, and accuracy were 93%, 93%, and 93%, respectively.

• Biopsy outcomes did not differ significantly over time during study span.