Olubamwo OO, et al. - Via a prospective epidemiological study involving 501 men without cardiometabolic disease (CMD) during an initial 4-year follow-up in the Kuopio Ischaemic Heart Disease Risk Factor Study cohort, experts investigated whether progressive fatty liver disease (FLD), as evaluated by fatty liver index (FLI), prognosticates increasing future CMD risk in comparison with relatively stable FLD, among middle-aged men. A total of 301 new CMD cases occurred during a mean follow-up of 15 years. Individuals with low baseline FLI were used and no significant 4-year FLI increase were included as the reference. According to findings, FLD development or progression is linked to an increase in risk of incident CMD. Those who progressed over the 4 years from low (normal) baseline FLI category already had risk comparable with that of individuals at intermediate baseline FLI category. Those who progressed over the 4 years from intermediate FLI category at baseline had risk comparable with that of individuals who maintained high FLI category both at baseline and at follow-up. Thus, with respect to clinical practice, people with significantly increasing FLI should be further assessed for new or progressive FLD to establish hepatic steatosis, presence of steatohepatitis, and degree of fibrosis. Such individuals should be assessed, monitored, and managed to prevent CMD development.