Florea A, et al. - In this investigation, 37 children followed in the National Referral Centre of the rare inflammatory brain and spinal diseases were involved to assess fatigue, depression, and quality of life (QoL) of children with multiple sclerosis and compare to other acute demyelinating syndromes (ADS). For evaluation, they used the Expanded Disability Status Scale, the fatigue severity scale, the Multiscore Depression Inventory for Children, and the Pediatric Quality of Life Inventory. Although not significant, patients with multiple sclerosis reported less frequent severe fatigue than children with ADS. Compared to the ADS group, depression was reported more often in the multiple sclerosis group. Regarding QoL in patients with multiple sclerosis, poor emotional and school functioning reported by both parents and children. This research underlined the significance of fatigue and depression in ADS children and especially in pediatric onset multiple sclerosis. In addition, the main concerns for parents and children in the multiple sclerosis group were difficulties in school and emotional functioning that need to be taken into account during their care and treatment proposal.