Banihani SA - Forty-nine semen samples of a normal count, motility, and morphology were involved wit an intention to calculate human sperm motility, viability, and DNA integrity of ejaculated human sperm in the presence of famotidine at 0, 0.1, 1 and 10 mM concentrations in vitro. On human sperm motility, sperm viability, and content of DNA breaks in sperm, famotidine at 0.1, 1 or 10 mM had an unimportant impact, in comparison with the control. Thus, famotidine at 0.1, 1 or 10 mM did not modify human sperm motility, viability or DNA integrity in vitro. Nevertheless, these findings symbolize the safety of famotidine in human sperm, additional in vivo studies are needed to ascertain the drug's safety.