Coutinho ER, Miname MH, Rocha VZ, et al. - The present study was conducted to correlate the characteristics of genetically defined familial hypercholesterolemia (FH) older individuals with age-matched non-FH counterparts. Researchers included 462 older than 60 years individuals, from 4,111 genotyped individuals(198 positive and 264 negatives for FH variants). The data exhibited that the genetic diagnosis of FH was correlated with higher atherosclerotic cardiovascular disease (ASCVD) rates, emphasizing the relevance of a monogenic defect as the cause of long-lasting hypercholesterolemia and ASCVD risk, especially in men, among hypercholesterolemic older individuals participating in a cascade screening program.