Peng SM, Hsu WF, Wang YW, et al. - Given that individuals with a positive fecal immunochemical test (FIT) have a much higher chance of advanced neoplasms vs the general population, experts assessed if FIT-positive patients with negative colonoscopy should receive subsequent FIT screening. They followed patients with a negative colonoscopy following a positive FIT in the first screening in the Taiwanese Colorectal Cancer (CRC) Screening Program (2004–2009) until the end of 2014. The sample included 9,179 patients with a negative diagnostic colonoscopy following a positive FIT in 2004–2009; 6,195 of these patients got a subsequent FIT during the study period. Findings suggested an association of higher baseline fecal hemoglobin concentration (FHbC, μg hemoglobin/g feces) with increased risk of incident CRC. In order to detect missed neoplasms and reduce the risk of incident CRC in the national FIT screening program, the subsequent FIT should be scheduled after negative colonoscopy.