Mayanja Y, Abaasa A, Namale G, et al. - Researchers conducted a prospective study of HIV negative female sex workers (18–49 years) to assess their vaccination completion and one-year retention in a simulated vaccine efficacy trial in Kampala, Uganda. Two hundred ninety volunteers (median age 27 years) were enrolled, and of these 230 reached one of these study end-points: 7 became HIV infected, 11 became pregnant, and 212 completed both the vaccination schedule and 12-month visit resulting in a retention rate of 77.9% (212/272). A vaccination completion rate of 82.4% was reported. Observations revealed that despite a substantial risk of HIV infection, female sex workers (FSWs) were willing to participate in HIV vaccine and prevention research. To increase participation in future HIV vaccine trials, a focus on empowering young FSWs and closely following those reporting genital ulcer disease symptoms should be priorities.