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Factors associated with antipsychotic use in non-psychotic depressed patients: Results from a clinical multicenter survey

BMC Psychiatry Feb 08, 2022

In this cross-sectional and multi-site study, the antipsychotics use and the associated factors are studied among non-psychotic major depressive disorder (MDD).

  • Among 1,503 eligible MDD patients included after 8–12 weeks of antidepressant treatment, the most commonly used adjunct to antidepressants was quetiapine (43.4%), followed by olanzapine (38.8%).

  • Commonly antipsychotics were used in combination with escitalopram (23.1%), venlafaxine (21.7%), sertraline (14.8%).

  • Overall non-psychotic MDD patients are commonly administered antipsychotics.

  • In non-psychotic depressed patients, following were the factors influencing the combination of antipsychotics: service setting, comorbidity of physical illness, PHQ level, SDS level and antidepressants co-treatment.

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