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Extended-pulsed fidaxomicin vs vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): A randomised, controlled, open-label, phase 3b/4 trial

The Lancet Infectious Diseases Mar 01, 2018

Guery B, et al. - Researchers performed a comparison of clinical outcomes of extended-pulsed fidaxomicin with standard vancomycin for Clostridium difficile infection in patients 60 years and older. Compared to standard-dose vancomycin, extended-pulsed fidaxomicin proved superior for sustained cure of C difficile infection. As per them, extended-pulsed fidaxomicin recurrence rates in this study were the lowest observed in a randomised clinical trial of antibiotic treatment for C difficile infection.
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