Jia M, Li FZ, Ye Q, et al. - Given that heat shock protein 105 (HSP105) is a protective protein that has long been observed in many cancer types but has received little attention in cutaneous squamous cell carcinoma (CSCC), researchers conducted this retrospective study to observe HSP105 expression on CSCC and assess its association with clinicopathological features. Participants in the study were 60 patients with CSCC. The patient’s clinical data, including gender, age, tumor location, tumor type, and degree of pathological differentiation, have been gathered. For the first time, the study shows that HSP105 expression is reduced in CSCC. The authors believe that the molecular mechanisms underlying HSP differential expression merit further investigation, the findings of which could explain its role in carcinogenesis and its potential as a target for selective tumor therapy.