Chia PL, Parakh S, Russell P, et al. - Since there is a lack of knowledge regarding the prevalence as well as the effect of conformational forms of epidermal growth factor receptor (EGFR) in malignant mesothelioma (MM), researchers explored expression of EGFR and conformational forms of EGFR via immunohistochemistry using EGFR-targeting monoclonal antibodies. Also, they used fluorescent in-situ hybridization to determine EGFR gene amplification. They correlated findings with survival. Using the thoracic surgery database of the Austin Hospital, Melbourne, Australia, they identified patients managed between 1988 and 2014. Overall 93% (299/321) of cases exhibited wtEGFR expression, with overexpression (defined as an H-score ≥ 200) evident in more than half of cases (64%). Findings revealed that high expression of EGFR was consistently shown by MM, with a subset of tumors demonstrating conformational EGFR forms consistent with EGFR dysregulation, but without EGFR amplification or EGFR VIII mutation. There was no impact of wtEGFR expression on survival. Further inquiry is warranted for the effect of EGFR conformation on survival.