Shi L, Zhang Q, Shou X, et al. - In patients with brain low-grade glioma (LGG), MTHFD2 was highly expressed, which linked with favorable overall survival of these patients.

• Patient’s age and IDH mutation status were related with MTHFD2 expression.

• The main location of MTHFD2 protein was the mitochondria.

• Desirably improved prognosis of LGG patients, especially for those patients with age ≥ 45 years, was observed in correlation with high expression of MTHFD2 in survival analysis.

• However, MTHFD2 did not appear to have an independent prognostic role in LGG.

• Considering the results from pathway enrichment analysis, it is assumed that MTHFD2 high expression possibly plays a critical role in LGG through positively regulating the pathway of one carbon pool by folate.