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Exposure to maternal depressive symptoms in fetal life or childhood and offspring brain development: A population-based imaging study

American Journal of Psychiatry May 11, 2019

Zou R, et al. - Researchers examined how child brain development, including volumetrics and white matter microstructure is linked to exposure to maternal depressive symptoms at various developmental stages from fetal life to preadolescence. From a longitudinal birth cohort in Rotterdam, the Netherlands, participants were 3,469 mother-child pairs with data on maternal depressive symptoms and child neuroimaging at age 10. Findings revealed a consistent association of perinatal maternal depressive symptoms with child brain development evaluated 10 years later. Results thereby indicate that for adversities such as maternal depressive symptoms, the postnatal period is a period of vulnerability.

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