Laporta ML, Kruthiventi SC, Stang CD, et al. - Researchers conducted this nested case-control study for analyzing the role of general anesthesia in the development of Parkinson disease and other α-synucleinopathies. From January 1991 to December 2010, all α-synucleinopathy cases in Olmsted County, MN, were identified from diagnostic codes, and then reviewed for type and index date of diagnosis. Four hundred thirty-one cases with clinically defined α-synucleinopathies have been identified. The authors found no evidence of a link between general anesthesia exposure and the risk of developing α-synucleinopathies.