Lai Q, Sapisochin G, Gorgen A, et al. - Among patients with hepatocellular carcinoma (HCC) awaiting a liver transplant, the risk of death could be reduced, by 33% to 49%, by undertaking living-donor liver transplant (LDLT).

• A multicenter cohort study with an intention-to-treat design of nearly 4,000 patients with HCC who were on a waiting list at transplant centers in Europe, Asia, the US, and Canada.

• LDLT had an independent protective effect, lowering the risk of intention-to-treat death in 4 different settings.

• Incorporation of LDLT in the mathematical models resulted in further improvement in their discriminatory ability.