Christian MT, Webb NJA, Mehta S, et al. - Researchers herein investigated if daily low-dose prednisolone given at the time of upper respiratory tract infection could aid in preventing upper respiratory tract infection–related relapse in children with relapsing corticosteroid-sensitive nephrotic syndrome.

• This is a randomized clinical trial (Prednisolone in Nephrotic Syndrome [PREDNOS] 2) including 365 children with relapsing steroid-sensitive nephrotic syndrome with and without background immunosuppressive treatment.

• No difference in the frequency of upper respiratory tract infection–related relapses was observed in correlation with providing daily low-dose corticosteroid therapy vs placebo.

• Overall outcomes do not support low-dose corticosteroid treatment as beneficial for preventing upper respiratory tract infection–related relapses.