Roden DF, Hobelmann K, Vimawala S, et al. - This retrospective case series was undertaken to determine if smoking history impacts survival in patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) who are treated with upfront transoral robotic surgery (TORS). The sample consisted of patients (n = 258; the average age was 60 years) with HPV-positive OPSCC who had upfront TORS at a single institution from 2010 through 2017. Using the Kaplan-Meier method and the log-rank test, recurrence-free survival (RFS), overall survival, and disease-specific survival were contrasted. No significant difference was noted in RFS between never and ever smokers, nor was there any disparity observed between never, former, and current smokers. In patients with HPV-positive OPSCC, a smoking history is common. In the current study, it was found that HPV-positive smokers, like their nonsmoking counterparts, have excellent survival and locoregional control. The outcomes do not endorse smokers' exclusion with early-stage, HPV-positive OPSCC from TORS–based deintensification trials.