Aldámiz-Echevarría T, Resino S, Bellón JM, et al. - Via a retrospective cohort study with HIV/ hepatitis C virus-coinfected patients who were possible candidates for therapy with interferon and ribavirin (IFN/Rib) between 2000 and 2009, researchers assessed if mitochondrial DNA haplogroups were correlated with liver-related events (LREs) in these patients. A total of 40 out of 243 included participants had advanced fibrosis or cirrhosis. Following a median follow-up of 7.7 years, 90, 18, and 11 patients treated with IFN/Rib attained sustained viral response (SVR), had LREs, and died, respectively. In comparison with patients with other haplogroups, patients with haplogroup H had lower cumulative incidence, while patients with haplogroup T vs patients with other haplogroups had greater cumulative incidence. Haplogroup T was correlated with an elevated hazard of developing LREs; haplogroup H was not linked to a lower hazard of LREs. Similar subhazard ratio values were achieved when patients who attained SVR during follow-up were excluded. The natural history of chronic hepatitis C may be affected by European mitochondrial haplogroups.