Herbert MS, et al. – Goals of this study were to investigate the association between cortisol and pain responses during a cold–pressor task (CPT) among African American (AA) and non–Hispanic White (NHW) adults with knee osteoarthritis (OA), also to evaluate the correlation between perceived racial discrimination and cortisol among AA participants. Cold–pressor pain responses were associated with pre–CPT cortisol concentrations in NHW persons with knee OA but not in their AA counterparts, consistent with previous findings in young healthy adults. To better understand this finding, additional studies were required.