Estimated GFR at dialysis initiation and mortality in children and adolescents
American Journal of Kidney Diseases Mar 06, 2019
Okuda Y, et al. - In this retrospective cohort study, researchers examined 9963 incident dialysis cases of age 1-17 years in the US Renal Data System registry to analyze the relation of mortality risk with estimated glomerular filtration rate (eGFR) at dialysis therapy initiation in candidates with kidney failure. They recorded median eGFR of 7.8 mL/min/1.73 m2 with the median age of 13 years. They observed 696 deaths during the median follow-up of 1.4 years and the overall crude mortality rate, 31 per 1000 patient-years. An association of eGFRs <5 and ≥12 mL/min/1.73 m2 with lower and higher mortality was found with adjusted HRs of 0.57 and 1.31, respectively while comparing with eGFRs of 7 to <9 mL/min/1.73 m2.
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