Mustafa K, Buckley H, Feltbower R, et al. - Given that cardiopulmonary arrests represent a major contributor to mortality as well as morbidity in pediatric intensive care units (PICUs), and acquiring insights into the epidemiology as well as risk factors for cardiopulmonary resuscitation (CPR) may inform national quality improvement initiatives, thus, researchers address this topic in this retrospective cohort study utilizing the Paediatric Intensive Care Audit Network database. Children who received CPR in 23 PICUs in England (2013–2017) were selected. Cumulative incidence of CPR was estimated to be 2.2% for 68,114 admissions over 5 years with an estimated incidence rate of 4.9 episodes/1000 bed days. Elevated odds of receiving CPR were observed in relation to factors such as cardiovascular diagnosis, age <1 year, the Paediatric Index of Mortality 2 score on admission and longer length of stay. A higher risk of receiving CPR in PICU was noted in children from Black and Asian racial/ethnic backgrounds vs White children. Findings generated in this first multicenter study from England offer not only a basis for further investigation but also evidence for benchmarking as well as quality improvement for prevention of cardiac arrests in PICU.