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Eosinophils in transbronchial biopsies: A predictor of chronic lung allograft dysfunction and reduced survival after lung transplantation

Transplant International Oct 12, 2020

Darley DR, Ma J, Huszti E, et al. - Given the inferior long‐term outcomes after lung transplantation relative to those of other solid organ groups, researchers investigated the significance of the identification of eosinophils on transbronchial biopsies (TBBx) after lung transplantation for determining long‐term outcomes. They conducted a retrospective single‐center cohort study reviewing 8,887 TBBx reports from 1,440 patients for the mention of eosinophils in the pathology report. Eosinophils were detected in at least one TBBx in 112 (7.8%) patients. Detection of eosinophils in TBBx was noted to be linked with an elevated risk of chronic lung allograft dysfunction and death. Findings suggest specifically reporting the presence of eosinophils in TBBx reports and incorporating their presence in clinical decision‐making, may be beneficial.

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