Miramontes-González JP, et al. - Researchers investigated if the expression of atherosclerotic cardiovascular disease (ASCVD) in familial hypercholesterolemia (FH) patients could be affected by polymorphisms in VEGFR2 and OPG genes. Using the SAFEHEART registry, a total of 318 FH patients without a clinical diagnosis of ASCVD were identified. According to the findings, the risk of ASCVD in FH patients was altered by polymorphisms in VEGFR2 and OPG genes. Reduced risk of developing coronary artery stenosis was noted in relation to homozygous GG genotype and G allele of VEGFR2 rs2071559 polymorphism. The risk of the presence of coronary artery calcium measured by coronary calcium score in coronary tomographic angiography was found to be increased in relation to being a carrier of the GG genotype and G allele of the OPG rs2073618 polymorphism.