Yan S, et al. - Investigators estimated 145 candidates to examine the effects of CRP polymorphisms on the susceptibility and therapeutic efficacy To investigate the impacts of CRP polymorphisms on the susceptibility and therapeutic efficacy in the South Han chronic spontaneous urticaria (CSU) cases. They found 62.50% of CSU cases effective when treated with mizolastine whereas 72.4% were effective in the desloratadine group. They observed a significant association of subjects carried with rs3093059TT genotype with good response and had lower serum CRP, IL-6 and TNF-α levels as compared to the CT/CC genotypes. Significantly higher luciferase activity vs wild allele was exhibited by the rs3093059C allele (in vitro). They concluded poor response of CSU patients carrying the rs3093059C allele to mizolastine with elevated serum CRP level.