Chen TK, et al. - This study was implemented to find out if the APOL1 risk variants are related to incident proteinuria in the context of hypertension-attributed CKD. Furthermore, it was also investigated if subsequent kidney function decline after the onset of proteinuria differs by APOL1 risk status. As per findings, the association of the APOL1 high-risk variants with greater risk of incident proteinuria was evident among blacks with established moderate CKD. A more rapid decline in kidney function occurred after proteinuria onset but it did not differ by APOL1 risk status, indicating that factors that lead to proteinuria, beyond APOL1, may additionally drive CKD progression.