Chaudhary NS, Moore JX, Zakai NA, et al. - Among black adults (n = 10,366) who took part in the Reasons for Geographic and Racial Differences in Stroke study, researchers investigated the links of apo L1 (APOL1) nephropathy risk alleles with risk of sepsis. These people were enrolled between 2003 and 2007 and were observed through December 31, 2012. The aforementioned links were assessed employing Cox models adjusted for demographics, comorbid conditions, and principal components ancestry, and using recessive (comparing zero or one vs two risk alleles), dominant (zero vs one or two risk alleles), and additive genetic models. The presence of two APOL1 risk alleles in 1,320 (13%) participants, one risk allele in 4,719 (46%), and zero risk alleles in 4,327 (42%) was reported. During a median 6.5 years, the occurrence of 306 sepsis events was documented. Findings revealed that carriage of APOL1 nephropathy risk alleles in community-dwelling black adults was common. In these people, a higher risk of sepsis was observed in relation to the presence of APOL1 nephropathy risk alleles.