Choby G, O'Brien EK, Smith A, et al. - Given that urine leukotriene E4 (uLTE4) is a biomarker of leukotriene synthesis and is elevated in patients with aspirin‐exacerbated respiratory disease (AERD), researchers conducted this retrospective analysis to determine whether uLTE4 biomarker levels are correlated with objective and subjective markers of disease severity in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). The sample consisted of CRSwNP patients who underwent uLTE4 testing was completed to determine the correlation of uLTE4 levels to markers of disease severity. Among the 157 patients with CRSwNP who met criteria for inclusion, uLTE4 levels were correlated with a history of asthma, aspirin sensitivity, worse Lund‐Mackay CT scores and other objective markers of disease severity including serum IgE, presenting blood eosinophil level, and the highest recorded eosinophil level. Findings suggested an association of elevated uLTE4 biomarker levels with worsened objective markers of disease severity in CRSwNP patients but not patient‐reported symptom measures.