Miranda DO, et al. - Whether or not pro-inflammatory cytokine levels are related to depression and anxiety in CRC patients in different stages of the antitumor therapy was determined. Positive associations of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α were demonstrated, while a negative correlation with IL-10 was also observed. These findings suggest the involvement of cytokines in the pathophysiology of these psychological disorders in CRC patients.