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Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes

BMC Cancer May 18, 2021

Wu A, Gao P, Wu N, et al. - Researchers investigated the prognostic worth of the percentage of mature monocyte in bone marrow (PMMBM) in a cohort of 216 myelodysplastic syndromes (MDS) patients in this retrospective study. Participants were split into elevated PMMBM group and the normal group by 6% PMMBM as the cut-off value. According to findings, a poor prognosis was reported in relation to increased PMMBM accompanied with higher frequency of IDH2 mutation. As a prognostic factor, PMMBM could provide assistance to IPSS-R (Revised International Prognostic Scoring System) to offer a convenient for measuring the prognosis of MDS cases particularly when their karyotype analysis fails.

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