Gunnarsdottir J, et al. - Researchers performed this population-based cohort study of 64,490 healthy primiparous women in order to determine the correlation between the change in systolic and diastolic blood pressure (BP) from early to mid-gestation and the risks of preeclampsia and birth of small-for-gestational-age (SGA) infants. Observations revealed a correlation of elevated diastolic BP from early to mid-gestation with increased risks of preeclampsia and SGA births. For preterm preeclampsia and SGA, the associations appeared stronger. This suggests the possible value of elevated BP from early to mid-gestation, in contrast to mid-gestation BP drop, as a sign of hemodynamic maladaptation to pregnancy in women who later develop placental dysfunction disorders. Furthermore, confirmation was made regarding the relevance of a second BP measurement around mid-gestation in the antenatal risk assessment.