Wang G, et al. - In patients undergoing coronary angiography (CAG)/percutaneous coronary interventions (PCI), a high level of asymmetric dimethylarginine (ADMA) level probably can serve as an independent predictor of mortality and cardiovascular events. Identification of blood ADMA level prior to CAG/PCI could add valuable clinical prognosis information.

• In this systematic review and meta-analysis, a total of nine prospective studies with 6374 participants were analyzed to evaluate the predictive value of the increased ADMA level in people undergoing CAG/PCI.

• Relative to patients with the lowest ADMA level, an elevated risk of all-cause death (risk ratio, 2.11), cardiovascular death (risk ratio, 2.95), major adverse cardiovascular events (risk ratio, 2.10) and restenosis (risk ratio, 4.57), respectively, was observed in patients with the highest ADMA level.