Fiene M, et al. - An analysis was performed to examine the neuromodulatory effect of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on objective measures of fatigue-related decrements in cognitive performance in multiple sclerosis (MS) patients. For the treatment of fatigue-related declines in cognitive performance in MS patients, tDCS-induced modulations of frontal activity could be an effective therapeutic option.